Domenico Ghirlandaio is chiefly known today for the fact that he had Michelangelo as an apprentice.
With relatives and, in particular, his brother Davide (1452-1525) he ran a big and successful studio. He preferred fresco to tempera, and never attempted oil painting.
Between 1481-82, he worked in the Sistine Chapel in the Vatican with Botticelli and others.
The Medici family gave him only one commission and there were no other commissions from any other well known patron.
He had a son, Ridolfo (1483-1562), a portrait painter who was heavily influenced by his friend Raphael
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